Let’s face it, Plague Inc. isn’t an easy game, and I think that’s because of how much depth there is to the game. It’s you versus the world, it shouldn’t be easy. It took me three games until I won, but before that I was becoming a bit frustrated. Games today make it very easy to win, to move on, but Plague Inc. requires the gamer to strategize, and adapt to the world’s tactics. This will be a short tutorial on how I won my first couple games, and how I am finding some success with the other diseases. Unfortunately, this strategy isn’t perfect, but it will spread to every country, even the Greenland (which can be a bitch if the world is researching a cure early one).
The first thing you want to do is begin in China because China is where the most people live. If your disease is infecting more people quickly, then you will gain DNA points faster. Another great thing about China is it is a part of the biggest continent, thus the disease has access to Russia, Europe, the Middle East, and Africa.
The first symptom to invest DNA into is ‘Coughing’, then ‘Cysts’ and ‘Rash’. Finally, invest points into transmission ‘Air 1′. This will grant access to ‘Sweating’ and ‘Hyper Sensitivity’ to infect Russia, Canada, and Greenland faster. I have found the cold climates to be the toughest to infect and kill with bacteria. The next investment is ‘Bacterial Resilience 1′. These will help the disease spread quickly, especially in hot and cold climates (China is neutral). We won’t pick any other transmission perks for now because we don’t know where the disease will have a hard time infecting. If the world, while researching a cure, notices animals, insects, etc are spreading the disease, they will begin exterminating them.
The disease should be infecting China rapidly at this point. Once the disease starts spreading, your DNA points will sky rocket. We need to keep this momentum going, or else the disease will fizzle once the world notices it’s spreading.
At this point, we will invest points into ‘Air 2′, and put points into both ‘Drug Resistance 1′ and ‘Drug Resistance 2′. China will have noticed the disease by now, but we wont be hasty and give our bacteria aggressive symptoms. When the world comes together to stop the disease, we will put out points into aggressive symptoms, but for now we will continue to make our disease very infectious.
To keep the momentum going still, invest points into symptoms show below. These will unlocks needed paths later, as well as increase infectiousness without making the disease lethal.

If the disease is not spreading in Africa and The Middle east, invest points into ‘Livestock 1′, ‘Blood 1′, and ‘Insect 1′.If the disease is not spreading in Europe and North America, invest points into ‘Rodent 1′ Greenland is tricky to infect because the disease can pass only by boat. If the world starts sterilizing boats, dump points into ‘Water’, and ‘Air 3′.

All countries should be infected at this point, and the world will be working on a cure. We have to act fast. We will invest points into ‘Insomnia’, ‘Paralysis’, ‘Seizures’, and ‘Insomnia’. These will make a cure harder to attain, and begin killing the population. We do not want to kill the population too fast, however, as the disease will kill all its hosts before finishing spreading. This is a frustrating way to lose! To be safe, we will also put points into ‘Genetic Reshuffle 1′ and ‘Genetic Hardening 1′.
When the disease has infected all humans, we can put all points into aggressive symptoms to kill the world before it finds a cure. In my current game, I put points into ‘Total Organ Failure’, which killed the population quickly.
Worst case scenario is a single country remains with a huge population that is healthy, and the disease is killing more people than it is infecting. If this happens, you should devolve symptoms that will kill its hosts, then try and invest points into abilities that would help the disease survive.

Here is my review for Plague Inc. Check back for more iPhone/iPad game app reviews.
Lastly, this was my first try at adding pictures to a post, so I am not sure how well it will look, and if I will keep doing it.

[...] Greenland is one of the hardest countries in Plague Inc. to infect because it’s cold, only path of spreading is by boat, and it has a small population spread thin. The easiest way to infect Greenland would be to start your disease there, however, that would slow your disease down, and increase the chances you can win with your disease. Start in China, like I mentioned in my guide to winning with bacteria. [...]
Omg thanks for this!! I FINALLY WON!!! XD
Congrats!
im glad this helped you guys, cuz it D**N sure didnt help me! i get tothe point where my infected goes down and my daeth goes up devolve things that will kill and STILL lose. i have evolved all the drug, strain, and bacteria AND the bas***ds still cure the thing!!!
Dude, this was awesome I won on my first try. Thank you so much!
Best way to win with bacteria in NORMAL mode is as follows:
1) Start in US. (TRUST ME)
2) Invest in Heat, Cold and Bacterial Resistance (level 1 for heat and cold; level 3 for bacterial resistance)
3) KEEP ALL SYMTOMS SUPPRESSED
This will allow disease to spread and survive without anyone detecting it. You will be able to infect most of the world this way, without detection, so no cure will be developed.
4) Once the spread starts to slow (after several billions are already infected) invest in livestock and bird transmission (both level 1)
5) Once the entire world is infected, Invest in following symptom sequence: coughing, sneeze, immune suppression, total organ failure
6) Sit back and watch the destruction. If cure develps too rapidly, you can invest in resistance abilities that alter the bacteria, but you probably won’t need to.
HOPE THIS HELPS!
this takes FOREVER…
it does work though.
A commenter suggest a method that plays quicker, in my opinion.
Thanks for the info.
Great post! :)
Your welcome. Thanks for commenting.
I’m thinking of re-writing this guide to be a bit more comprehensive, and in-depth. Not sure yet, though
Nice! I was stuck for a while and your post really helped. Thanks!
if this fails and your having trouble but you want to get passed the bacteria part, start in china complete the water and air so its very infective and add cold abiity level one then every time the bacteria evolves on its own devolve it straight away this make take a bit longer but people will never start the cure and the whole world will be infected then because you’ve saved over 150 dna points just maximise the lethality then the world will die out its not the most fun way but it gets it done just remember to be patient and don’t start killing people until every person is infected
did this, but my cure is up to 80% and i have NO DNA and every person is infected…
Make sure to keep lethality down to a minimum until the entire world population is infected. After that, you can refund skills that help your disease spread to buy skills that make your disease more lethal. If your disease mutates lethal skills early, refund them
It did not work
They’ve updated the game twice since this guide. I may make a new one
Worked for me first try. It may not work every time, but you have to adapt to what the game gives you. That guy should have been more descriptive anyway.. “it didn’t work” tells us nothing.
These tips are still applicable though, and I think China is still one of the best places to start.
One thing that helps me that wasn’t really touched on in the guide is to keep an eye on your infectivity and severity on the Disease screen, and make sure your lethality never goes above either of these until the final phase of killing everyone off. If you’re following the guide properly though this shouldn’t happen.
Thanks for the support :)
This is a good tip, watching infect ivory and lethality that is.
I am planning on writing a new guide that has more depth, sometime in November on a weekend perhaps. I followed GamerTips on twitter if that is in fact you
Thanks for the comment again,
This is an awesome guide! I have been having trouble trying to beat the game at a “Normal” difficulty. This seriously helped a lot. Hope to see more from you and thanks for the guide!
Thanks for kind comment :)
There will be more from me !
thanks this worked well for me
Great ! :)
This guide worked for me! China is definitely the place to start off!
Thanks again!
T.
Was that the name of your disease?
And happy you won!
Got bacteria and then virus using this tactic
Congrats man
:) woot a breakthrough! Great strat, worked like a charm!
Happy to hear!
It worked! Thank you.
Great to hear!
Dude your strategy owned the game!
:)
I didn’t work for me while the cure only hit 37 for you and the symptoms you had didn’t kill anyone on mine not only did it kill people but the cure was complete before everyone was infected
:(
Did not work for me
this worked perfectly on easy, however when doing medium, I cannot even infect Madagascar, so my infection kills everyone in the world except those in Madagascar, any thoughts on how I can infect and kill Madagascar ? :) thankyou
Thanks man, this really helped. I’ve tried at least 20 times, but when I tried your method, I got it on the first try.
Thanks! i named mine Vicoccus-X
That is a bad ass name for a virus. I default to magic mint for my virus names. I feel uninspired
Greenland didn’t get infected.
Try try try again
Thanks! I unlock the Virus game.. I won!. Make same tips on Virus game :)
This winter season I will be working on one as I feel this one is out of date and this game has had so many updates
Green land is hard to infect. But i did a whole lot better with this guide. Thanks alot!
Damnit Africa
USELESS PIECE OF SHIT!!!!
Never trust this stupid guide it will never help you guys……
The way you phrase your negativity makes me think it was just operator error.
Thanks :)
This totally worked for me!! they only got to 63% and BAM! they were all dead.
Thanks so much!
I enede up wiping out every country but greenland
GOD DAMN GENIUS I did it on my third try and I just watched greenland slowly widdle away to nothing
Congrats :)
It’s still not working for me :( Like I’ll get to everyone being infected (though often had to buy Livestock, Insect, etc and Heat and Cold for it to get to Greenland) but then my DNA points slow down and thus by then I can’t kill everyone else and also use the Bacterial Reshuffles to slow down the cure. So I always lose because I either slow down the cure but can’t kill everyone before the cure finishes or I start killing people but too many are cured. :(
Yeah my guide has been hit or miss for people. I’m planning on writing a new one, which would be more in depth (if possible)
So the way that works for me is to start in greenland and de-evolve any mutations that arise until literally the whole planet is infected with a disease that does nothing. Then up the resistance and ability to find a cure and pick one or two severely lethal pathes depending on the news articles that have come up. If the world is better at fighting tumors, steer clear of tumors, etc. Good luck!
thx!!! it really helped me! i had been trying to defeat it in normal (yes NORMAL) for like 2 weeks and the humans always died before they could infect the others! thx again
Okay Im a bit condused. When all the countries get infected you said to put your points in insomnia, paralysis, seizures, &insomnia.
You wrote 2 insomnias. Did you mean insanity or something? Was it a typo, cuz im really confused if someone knows plz help
Looks like a typo. Pretty confident I meant insanity